药物化学杂志 SCIE

期刊简介估计审稿时候： 约2.1个月

The Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.

Some specific areas that are appropriate include the following:

* Design, synthesis, and biological evaluation of novel biologically active compounds, diagnostic agents, or labeled ligands employed as pharmacological tools.

* Molecular modifications of reported series that lead to a significantly improved understanding of their structure-activity relationships (SAR). Routine extensions of existing series that do not utilize novel chemical or biological approaches or do not add significantly to a basic understanding of the SAR of the series will normally not be accepted for publication.

*Structural biological studies (X-ray, NMR, etc.) of relevant ligands and targets with the aim of investigating molecular recognition processes in the action of biologically active compounds.

* Molecular biological studies (e.g., site-directed mutagenesis) of macromolecular targets that lead to an improved understanding of molecular recognition.

*Computational studies that provide fresh insight into the SAR of compound series that are of current general interest or analysis of other available data that subsequently advance medicinal chemistry knowledge.

* Substantially novel computational chemistry methods with demonstrated value for the identification, optimization, or target interaction analysis of bioactive molecules.

* Effect of molecular structure on the distribution, pharmacokinetics, and metabolic transformation of biologically active compounds. This may include design, synthesis, and evaluation of novel types of prodrugs.

* Novel methodology with broad application to medicinal chemistry, but only if the methods have been tested on relevant molecules.

《药物化学杂志》颁发的研讨有助于懂得份子布局与生物活性或感化体例之间的干系。

一些恰当的特定范畴包含：

* 设想、分解和生物学评估用作药理学东西的新型生物活性化合物、诊断剂或标记配体。

* 对已报道的系列停止份子润色，从而明显进步对其布局-活性干系 (SAR) 的懂得。现有系列的惯例扩大，若是不接纳新的化学或生物学体例，或不明显增添对系列 SAR 的根基懂得，凡是不会被接管出书。

*相干配体和靶标的布局生物学研讨（X 射线、NMR 等），旨在研讨生物活性化合物感化中的份子辨认进程。

*大份子靶标的份子生物学研讨（比方，定点诱变），可进步对份子辨认的懂得。

*计较研讨，为以后遍及感乐趣的化合物系列的 SAR 供给新的看法，或阐发其余可用数据，从而增进药物化学常识。

*具备明显代价的本色上新颖的计较化学体例，可用于生物活性份子的判定、优化或靶标彼此感化阐发。

*份子布局对生物活性份子的散布、药代能源学和代谢转化的影响化合物。这可以或许包含新型前体药物的设想、分解和评估。

* 普遍利用于药物化学的新体例，但条件是这些体例已在相干份子上停止了测试。

《Journal Of Medicinal Chemistry》(药物化学杂志)编辑部通信体例为AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, USA, DC, 20036。若是您须要辅佐投稿或润稿办事，您可以或许征询咱们的客服教员。咱们专一于期刊征询办事十年，熟习颁发政策，可为您供给一对一投稿指点，防止您在投稿时频仍碰鼻，节流您的可贵时候，有用晋升颁发机率，确保SCI检索（检索不了全额退款）。咱们视诺言为生命，多方面确保文章宁静失密，在任何环境下都不会泄漏您的小我信息或稿件内容。